America's North Shore Journal

Supporting the Ninth Amendment

US military assisting in Ebola outbreak

Ebola virus research is conducted in maximum containment Biosafety Level 4, or BSL-4, laboratories, where investigators wear positive-pressure suits and breathe filtered air as they work.

Ebola virus research is conducted in maximum containment Biosafety Level 4, or BSL-4, laboratories, where investigators wear positive-pressure suits and breathe filtered air as they work. Here, scientists Gene Olinger (L) and James Pettit demonstrate BSL-4 laboratory procedures in BSL-4 training laboratory at US Army Medical Research Institute of Infectious Diseases (USAMRIID), Fort Detrick, Md. (Credit: USAMRIID)

This is some background on the efforts by the U.S. military to combat Ebola. It also includes information about the development of ZMAPP, the experimental treatment being used on some Ebola patients in the current outbreak in West Africa. For more information about the two current Ebola outbreaks, please visit our Ebola resources page.

Defense Threat Reduction Agency
Chemical and Biological Technologies Department
Story by John Davis

Dec. 2, 2013 – New developments using monoclonal antibodies (mAbs) to block Ebola infection and even to treat after symptoms appear show promise in protecting warfighters and first responders. DTRA CB/JSTO-funded research by Mapp Biopharmaceutial, Inc. (San Diego, Calif.), working with the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID – Frederick, Md.), looked at the design, production, and testing of mAbs targeting the Ebola virus (EBOV) glycoprotein as a means to block the infection process.

Results from this work could ultimately give warfighters and first responders better protection and treatment against Ebola, an issue of increasing importance as human incursions into endemic regions occur more frequently.

It is particularly compelling that the mAbs demonstrated effectiveness in infected primates, even after symptoms developed greater than four days after Ebola exposure (i.e., a realistic “trigger-to-treat” scenario). EBOV is a highly lethal disease that can quickly overwhelm its hosts’ immune system. To rigorously test the potential of their mAbs, scientists implemented a study protocol to mimic a disease treatment scenario, where the initial exposure to an infectious agent, such as Ebola, goes undetected. In this study, none of the infected subjects received the mAbs treatment until clinical signs (fever) and confirmation of the infectious agent (circulating virus particles) could be detected.

The work is detailed in the journal Science Translational Medicine article, “Therapeutic Intervention of Ebola Virus Infection in Rhesus Macaques with the MB-003 Monoclonal Antibody Cocktail,” where the researchers, in collaboration with USAMRIID, used sophisticated telemetry methods to monitor body temperature and a virus diagnostic protocol that detected Ebolavirus in the primates’ blood. The authors point out that, “the ability to treat at a later time point after initial exposure and to mitigate further morbidity and disease pathogenesis underscores the therapeutic potential of mAbs.”

Another benefit to Mapp’s mAbs is that, while originally derived from mice, Mapp has already “chimerized” the murine mAbs with human mAbs. This limits the human immune system from responding to mAbs treatment, thereby improving safety and likely prolonging their effectiveness in humans. With these advances, further study of the mAbs might one day support their advancement into human testing.

The Jeanswear coalition accounts for 25% of total revenue and 28% of coalition operating income. The two brands leading the portfolio are Wrangler and Lee. Mirror’s Edge was a first person parkour game starring an Asian woman Replica ray bans a collection of wildly innovative ideas from EA, a company known for the exact opposite. If Wholesale China Jerseys it sounds strange to you, you’re having the same reaction everyone had before they played it. The other measurement with the skateboard truck is going to be just variations with the tightness of the truck. So that is just personal preference. As it not actual etching, in the sense that it eats away material, you will end up with very fine glass dust, and sometimes depending on the glass really small glass splinters. These easily make it into your skin if you not careful, or god forbid into your system when using the glasses. Now turning to guidance for fiscal ’17, as Bob previewed we believe Lids is positioned for meaningfully better Cheap NFL Jerseys performance and that Journeys and Johnston Murphy will continue the solid trends they are on. And Canada. Using the art of disguise, Arya sneaks into the home of her archnemesis and murders his sons dead. After the chilling triple kill, she bakes Frey a meat pie containing his own progeny and savors the moment as he chows down on his babies. (3) cheap oakleys Ask what you will Jesus understood that if we are saved and diligently read and study the word of God, it would in turn affect our will and cause our will to be comformed to the will of God. This means that our prayers would be saturated with God’s word (His will), therefore, we would not ask Him to do anything against His written will for our lives.. “The report myopically ignores commitments just a few months back, 13 major banks announced a landmark $20 billion commitment to increase lending to small businesses in underserved communities,” said Elise Brooks, director of communications for The Financial Services Roundtable, an association that represents the nation’s largest banks, insurance ray bans sale companies, securities firms and other financial institutions. “Additionally, small business lending is more than just providing the financing for the loans themselves. At the same time, Novo Nordisk trades at a similar valuation to this crew but is are actually growing 7% in local currencies. In fact, the stock sold off a few weeks ago because it reduced expectations to only grow at 5% to 7%. I tell cheap ray bans the coach up front what I was doing and I was not going to embarrass anybody. When I arrived, they were guarded at first.
If this post helped you, why not buy me a cup of coffee?

Running this website costs time and money. If you would like to make a small donation supporting the site, click here.

America's North Shore Journal © 2014 Frontier Theme