Bird flu risk far from over
Thursday, February 15th, 2007Here are some snips from the article. Worth a look. The usual doomsayers, Osterholm and Webster, get the big quotes. My take at the end of the piece.
“I’ve gotten at least 10 media calls in the last few months asking me to deliver the death sentence for avian flu,” said Michael Osterholm, director of the Center for Infectious Disease Research and Policy at the University of Minnesota. “But at any conference, if you get a group of virologists at the bar, after the fourth beer, they let their hair down and admit it — they don’t know what is happening. They’ve been incredibly humbled by this virus.”
Robert Webster, a virologist at St. Jude’s Children’s Research Hospital in Memphis, ended a talk with a slide of three animals in a reference to Asia. “We’ve survived the Year of the Chicken and the Year of the Dog,” he said. “Will we survive the Year of the Pig?”
The Year of the Pig begins Sunday, and the Lunar New Year celebrations in China and Vietnam have become associated with flu outbreaks because so much poultry for family feasts is on the move. “My take-home message,” Webster added, “is don’t become complacent. Don’t trust this one.”
But the virus is out of control in poultry in three countries — Indonesia, Nigeria and Egypt — with combined populations of 447 million people. A year ago, it was out of control only in Indonesia, and Thailand and Vietnam had stifled outbreaks, although the virus returned. China remains a mystery — despite official denials, there is evidence that it is circulating there.
Most alarming to the experts, although it got relatively less attention, was the death last month of a 22-year-old Nigerian woman, an accountant who lived in the crowded financial capital, Lagos.
Officially, only one death from H5N1 was confirmed, but Nigerian newspapers said the woman’s mother died with similar symptoms two weeks earlier, and a female relative was sick but recovered. If true, that suggests a cluster of cases with possible human-to-human transmission. Tests on them were negative, but human H5N1 tests are best done on fresh samples from deep in the lungs, which are hard to obtain, and false negatives are common.
In Nigeria, despite the culling of 700,000 birds, the flu has been found in 19 of 36 states, said the UN Food and Agriculture Organization.
Oyedele Oyediji, president of a Nigerian veterinarians’ association, told local newspapers that bans on poultry movement and culling orders were simply not being enforced. “If you go to the markets in Lagos now,” he said, “you would notice that poultry products like guinea fowl, ducks, turkey and chicken from the northern part of the country are still available.”
Nigerian farmers have complained that government cullers pay them only $2 for chickens that cost them $5 to $7 to raise. But payments, supported by the World Bank, seem to be made fairly promptly through local police stations.
Indonesia, by contrast, provides farmers with $1 vouchers that may not be cashed for three or four months, said Tri Satya Putri Naipospos, the country’s chief veterinarian. “It’s our weakest implementation,” she admitted. “It should be treated as an emergency, but we still follow routine budget mechanisms.”
Eighty percent of all Indonesian households keep poultry, she said, the flu is in 30 of 33 provinces and still few take the threat seriously enough. “Farmers say dying chickens are normal in life,” she said. “And you must realize that 62 dead people in one and a half years? That’s not very much in Indonesia. Three hundred thousand die from TB, from dengue. People in the villages don’t grab what is a pandemic.”
World Health Organization reports almost always link human cases to proximity to dead poultry, but Naipospos, the Indonesian flu expert, released data at a flu conference in Washington on Feb. 1 calling that into question. In the 82 human cases studied, she said, only 45 percent of victims had direct exposure to sick poultry.
An additional 35 percent had “indirect” exposure, which meant sick birds in the neighborhood, and 20 percent were “inconclusive.” “Unlike in Thailand and Vietnam,” she said, “our risk factors are not clear.” Virologists believe that the situation that must be avoided at all costs is to have humans with seasonal flu catch H5N1, too, because the viruses could mix.
Indonesia’s best prevention against that, Naipospos said, is the “Tamiflu blanket.” “We learned that in Garut,” she said of a cluster of cases last August in West Java. More than 20 people died or suffered serious symptoms.
The government quickly gave the antiviral drug to more than 2,000 people.
Ultimately, only three cases in the cluster were confirmed, but scientists suspected some were missed and the drug suppressed the virus to undetectable levels in others.
Despite what the learned doctors say, it may be that the ordinary Indonesian is correct. 62 versus 300,000. It is not a big deal at this time and may never be.
Let’s be very realistic. If this becomes a pandemic, there’s not a damn thing we can do about the millions who will die in the Third World. Tamiflu is not 100% effective, and it must be given daily for the life of the pandemic. There just aren’t that many doses and there will not be. Even if the medicine exists, religious and social restrictions will come in to play, just as the Moslems limiting the polio vaccinations in Nigeria created an epidemic throughout Africa and Asia.
And, just how do you propose to deliver this medicine? Bad weather, bad roads, not enough medical personnel.
However, if Drs. Osterholm and Webster could just get a few million more dollars for research, we may all be saved.

