Neoma O. C. Smiths parents were Wyat Smith born abt 1768 in South Carolina and Margaret Peggy Kaigler born 1770 South Carolina. There is not indication that either of the individuals were Indian either.

Each of us has 62 ancestors between us and the great-great-great-grandparent generation of our ancestry. If Neoma was Cherokee (which she likely was not, see below), that means that Warren is arguing she’s a minority because one of those 62 ancestors was Indian. That proposition is ludicrous, and offensive to actual Native Americans.
But it’s unlikely Neoma was Indian. The only document suggesting she was Indian was the 1894 marriage certificate for her son, William J. Crawford, who supplied the information to county officials.

But this secondary documentation is completely contradicted by the 1830, 1840, and 1860 US Censuses where she and her children are listed as White. If she was an Indian, she would have been reported as such by the enumerator.

In 1830, the US Census lists her and her entire family as White (“No. of Free White Persons: 6; No. of Others: 0). 1830 US Census, Tennesee, Bledsoe County, page 274. In the US Census of 1840, Neoma and her family are all listed as White (“No. of Free White Persons 10″). 1840 US Census, Tennesee, Jackson Co., District 4, page 4. In the 1860 US Census, Neoma — by then a widow — is listed as White, as are all her children.

So official US documents over 30 years list her as White; it isn’t until the 1894 marriage certificate of her son that any recorded mention is made of her being Cherokee.

Finaly, note that the name Neoma is not Indian, as some have suggested. Neoma is a Greek-derived name from the Greek elements neos (new) and mene (moon) meaning “new moon.” It is not Indian. While not common, it does occur with some frequency in the early 1800s into the late 1870s, especially in the South

Neoma was born in 1794, North Carolina and died after 1860 in Overton, TN. She never went to Oklahoma. At least one source says her parents were Wyatt Smith and Peggy Brackin(sp) Smith

Sounds like the point of contention is on the Crawford line, but there appears to be another generation worth of documentation on the Clark line, here, and elsewhere: http://archiver.rootsweb.ancestry.com/th/read/CLARK-WV/2003-10/1066909558

The references that you cited are out of date and incomplete. There are several more recent scientific publications, which I’d encourage you to read. Here are a few:

Neurocognitive functioning in youth with pediatric autoimmune neuropsychiatric disorders associated with streptococcus. Lewin AB, et al. (September, 2011)

Clinical Factors Associated with Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections. Murphy, TK, et al (2011)

The Immunobiology of Tourette’s Disorder, Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcus and Related Infections: A Way Forward. Murphy, et al (2010)

Maternal history of autoimmune disease in children presenting with tics and/or obsessive–compulsive disorder. Murphy, et al (2010)

Passive transfer of streptococcus-induced antibodies reproduces behavioral disturbances in a mouse model of pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection. Yaddanapudi, K et al (2009)

Are antibasal ganglia antibodies important, and clinically useful? Martino, et al (2007)

Streptococcal Mimicry and Antibody-Mediated Cell Signaling in the Pathogenesis of Sydenham’s Chorea, Kirvan, et al (2006)

There is an IVIG study for PANDAS children currently underway at the NIMH (as well as other related studies). For information regarding the NIMH study – currently recruiting as of this date: http://clinicaltrials.gov/ct2/show/NCT01281969?term=ivig+pandas&rank=1 In the meantime, I’d encourage you to review this one:

Therapeutic Plasma Exchange and Intravenous Immunoglobulin for Obsessive-Compulsive Disorder and Tic Disorders in Childhood. Perlmutter, et al (1999)

Denise Greaud Grubbs, RN
PANDAS-PITAND Awareness & Research Support, Director